Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation
M. Sh. Khubutiya,
V. O. Aleksandrova,
A. G. Balkarov,
V. E. Vinogradov,
N. V. Zagorodnikova,
R. V. Storozhev,
N. V. Shmarina,
N. V. Borovkova,
I. V. Dmitriev https://doi.org/10.20340/vmi-rvz.2023.2.TX.1
Abstract
The origin of the recipient is one of the recipient-related factors that statistically significantly affects the outcomes of kidney transplantation, but this factor is not so relevant in our country. The article presents the first experience of kidney transplantation in a patient of African descent at the N.I. N.V. Sklifosovsky.
Material and methods. Allogeneic renal graft transplantation from a post-mortem donor was performed in a 60-year-old African male patient with stage 5 chronic kidney disease as a result of hypertensive nephroangiosclerosis.
Results. The early postoperative period was complicated by the development of acute cellular graft rejection grade 1a-b according to Banff. Anti-crisis therapy was performed with some positive effect, however, in the late postoperative period, a loss of renal graft function was noted, and the patient was returned to renal replacement therapy with program hemodialysis.
Conclusion. Patients of African ancestry are at increased risk of adverse outcomes due to immunological causes and require more careful immunological selection of a donor organ, an enhanced immunosuppressive regimen, and close monitoring after transplantation.
About the Authors
M. Sh. Khubutiya
N.V. Sklifosovsky Research Institute of Emergency Medicine;
Moscow State Medical and Dental University named after A.I. Evdokimov;
Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow
Russian Federation
Russian Federation
Mogeli S. Khubutiya, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya
Square, Moscow, 129090;
Department of Transplantology and Artificial Organs, 20, p. 1, Delegate, Moscow, 127473;
Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088
V. O. Aleksandrova
N.V. Sklifosovsky Research Institute of Emergency Medicine
Russian Federation
Russian Federation
Veronika O. Aleksandrova, Department of Kidney and Pancreas Transplantation,
3 Bolshaya Sukharevskaya Square, Moscow, 129090
A. G. Balkarov
N.V. Sklifosovsky Research Institute of Emergency Medicine;
Pirogov Russian National Research Medical University;
Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow
Russian Federation
Russian Federation
Aslan G. Balkarov, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;
Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997;
Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088
V. E. Vinogradov
Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow; City Clinical Hospital No. 52 of the Moscow City Health Department
Russian Federation
Russian Federation
Vladimir E. Vinogradov, Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088;
Consultative and Diagnostic Nephrological Department, 3 Pekhotnaya, Moscow, 123182
N. V. Zagorodnikova
N.V. Sklifosovsky Research Institute of Emergency Medicine
Russian Federation
Russian Federation
Natal'ya V. Zagorodnikova, Department of Kidney and Pancreas Transplantation,
3 Bolshaya Sukharevskaya Square, Moscow, 129090
R. V. Storozhev
N.V. Sklifosovsky Research Institute of Emergency Medicine
Russian Federation
Russian Federation
Roman V. Storozhev, Department of Kidney and Pancreas Transplantation,
3 Bolshaya Sukharevskaya Square, Moscow, 129090
N. V. Shmarina
N.V. Sklifosovsky Research Institute of Emergency Medicine;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Nonna V. Shmarina, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;
Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997
N. V. Borovkova
N.V. Sklifosovsky Research Institute of Emergency Medicine;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Natal'ya V. Borovkova, Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997;
Department of Biotechnology and Transfusiology, 3 Bolshaya Sukharevskaya Square, Moscow, 129090
I. V. Dmitriev
N.V. Sklifosovsky Research Institute of Emergency Medicine;
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Il'ya V. Dmitriev, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;
Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997
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Review
For citations:
Khubutiya M.Sh., Aleksandrova V.O., Balkarov A.G., Vinogradov V.E., Zagorodnikova N.V., Storozhev R.V., Shmarina N.V., Borovkova N.V., Dmitriev I.V. Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2023;13(2):112-116. (In Russ.) https://doi.org/10.20340/vmi-rvz.2023.2.TX.1
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