The relevance of the problem of post-stress depression is explained by its high prevalence, significant socioeconomic consequences, and the low effectiveness of existing therapeutic approaches. The pathogenesis of depression, as a heterogeneous disorder, is due to multiple predisposing factors and diverse biological mechanisms; therefore, a unified concept of its origin has not yet been developed. This stimulates the intensification of research in the direction of finding new diagnostic markers and therapeutic strategies for the treatment of depression. The set of biologically active compounds of dandelion extract determines its potential effectiveness in the treatment of depressive states.

The aim of the study was to investigate behavior patterns in rats under conditions of stress-induced depression after an intragastric load of dandelion extract.

Materials and methods. The study was conducted on 90 six-month-old male Wistar rats. A "social" stress model was used to simulate the depressive state in animals. All animals were equally divided into 3 groups of 30 rats each, according to the randomization principle: Group 1 — intact animals, to which no effects were applied; Group 2 — control, in animals a depressive state was modeled, and they received intragastrically distilled water, in a volume of 2 ml daily for 20 days from the moment of depression modeling; Group 3 — males, which from the first day of depression modeling received intragastrically an aqueous extract of dandelion medicinal plant, produced by KorolevPharm LLC with a concentration of active substances of 3.5-4.0%, at a dose of 75 mg/100 g of animal weight, in a volume of 2 ml. Behavioral patterns were studied in animals on the 21st day of the experiment using the behavioral despair tests according to the Porsolt method, Open Field and Elevated Plus Maze. Digital data from all experiments were statistically processed using parametric and nonparametric analysis methods.

Results. It was found that depressed animals exhibited decreased active swimming time and increased passive swimming and immobilization time. However, aggressive and submissive rats treated with dandelion extract for depression demonstrated less pronounced depressive symptoms compared to untreated animals. Results from the Open Field and Elevated Plus Maze tests revealed that aggressive and submissive rats exhibited increased anxiety during stress-induced depression, manifested by decreased vertical and horizontal activity, increased grooming time, and increased fecal bolus production. Biologically active substances in dandelion extract are capable of inducing inhibitory processes in the nervous system and reducing psychoemotional stress in animals in the open field, elevated plus maze, and Porsolt tests. This is due to their ability to activate protective inhibition processes in the central nervous system, resulting in a reduction in psychoemotional stress in rats. Consequently, these compounds exert stress-protective and antidepressant effects.

Conclusions. Intragastric administration of dandelion extract to rats with aggressive and submissive behavior patterns in a state of social depression helps reduce the manifestations of depression.

Systemic activation of the humoral immune system occurs in malignancies, autoimmune diseases, infections, and pregnancy, yet its quantitative assessment with simple laboratory tools remains challenging. We developed a rapid, low-cost latex agglutination test (LAT) as an antigen-agnostic sensor of systemic humoral activation. The assay measures visual agglutination of uncoated 2-μm latex microspheres by serum antibodies and reports a semi-quantitative titer (highest dilution with visible agglutination). Sera from cancer patients, pregnant women, and healthy volunteers were tested. Uncoated beads revealed increased systemic activity in select groups: in breast cancer (n=11), 73% maintained low titers (≤1:8) while 27% showed therapy-associated rises up to 1:64; HER2-positive cases exhibited transient or sustained elevations during targeted therapy, and CDK4/6 plus endocrine therapy showed delayed increases. Pregnant women displayed high titers (1:32–1:64), and healthy volunteers were negative. These data indicate that LAT captures systemic activation and can distinguish therapy-associated increases, supporting its use as a universal serological marker that complements antigen-specific assays in clinical and research settings.

Relevance. Abdominal wall hernias remain one of the most common surgical conditions, and the frequency of their development and recurrence is largely influenced by modifiable risk factors. Since these factors are subject to correction, their study is crucial for improving preventive strategies and treatment outcomes.

The aim of this study is to summarize and analyze current scientific data regarding the role of modifiable risk factors in the development of external abdominal hernias.

Materials and methods. A literature review was conducted using PubMed, Scopus, Web of Science, and eLIBRARY databases. Publications from 2015 to 2025 were included, focusing on the pathogenesis, clinical relevance, and corrective potential of modifiable risk factors for abdominal wall hernias.

Results and discussion. Obesity, smoking, chronic cough, physical inactivity, constipation, impaired nutrition and collagen synthesis, and excessive physical exertion were identified as significant modifiable factors that increase the risk of hernia development. These factors exert their effects by increasing intra-abdominal pressure, impairing wound healing, and weakening fascial structures. Timely correction of these factors can significantly improve outcomes, reduce recurrence rates, and enhance the effectiveness of hernia repair. Conclusion. Identification and modification of risk factors should be considered essential components of a comprehensive approach to the prevention and management of external abdominal hernias.

Gestational diabetes mellitus (GDM) is a serious problem in obstetrics, especially in combination with polymorbid pathology. The introduction of an interdisciplinary approach to pregnancy management makes it possible to minimize risks and improve the quality of medical care.

The purpose of this work is to evaluate the features of pregnancy management in a patient with diagnosed GDM and concomitant diseases, to analyze the effectiveness of modern clinical recommendations and interdisciplinary interaction in reducing obstetric and perinatal complications.

Materials and methods. The study examined a clinical case of a patient with GDM on the background of polymorbid pathology. To assess the patient's condition, laboratory and instrumental research methods were carried out as part of prolongation of the present pregnancy, treatment of the detected pathology and preparation for the upcoming birth through the natural birth canal under CTG control, as well as prevention of bleeding from the end of the second period of labor.

Results. Positive dynamics was observed against the background of the therapy.

Conclusions. An interdisciplinary approach to pregnancy management in a patient with GDM and polymorbid pathology allowed minimizing the risk of obstetric and perinatal complications. The use of modern clinical recommendations, including personalized nutrition, glycemic control and timely medication correction, ensured a favorable pregnancy outcome for both mother and child.

Background. Severe thoracic trauma is characterized by high mortality (27–35%) among working-age individuals. The main causes of unfavorable outcomes include rapidly progressing intrathoracic complications and the development of infectious processes in 65–70% of deceased patients.

Objective. To evaluate the effectiveness of valve thoracostomy using an original drainage device in the prevention of early intrathoracic complications in patients with severe thoracic trauma compared with standard drainage methods.

Materials and methods. A prospective cohort study was conducted involving 250 patients with severe thoracic trauma admitted to the N.V. Sklifosovsky Research Institute for Emergency Medicine and Pushkin Clinical Hospital from January 2020 to December 2024 (protocol approved by the local ethics committee No. LEC-2019-084). Patients were allocated into two groups: the study group (n=130) with the use of an S-shaped drain with a one-way petal valve, and the control group (n=120) with standard tube drainage. Inclusion criteria: isolated severe thoracic trauma with ISS 16–25 points, age 18–65 years, presence of hemopneumothorax. Exclusion criteria included concomitant traumatic brain injury, ISS greater than 25 points, and multiple organ failure at admission. The primary endpoint was the incidence of infectious complications; secondary endpoints included length of hospital stay, recurrent pneumothorax rate, and gas exchange dynamics (PaO₂/FiO₂). Statistical analysis was performed using the χ² test for categorical variables and the Mann–Whitney U test for continuous variables at a significance level of p<0.05. Results. In the study group, the incidence of infectious complications was 8.5% (11/130) compared with 23.3% (28/120) in the control group (χ²=11.24, p=0.001; OR=0.31, 95% CI 0.15– 0.64). The median length of hospital stay for isolated severe thoracic trauma was 6 days [IQR 5–8] in the study group versus 13 days [IQR 10–16] in the control group (U=2847, p><0.001). Recurrent pneumothorax developed in 1.5% (2/130) of patients in the study group versus 7.5% (9/120) in the control group (χ²=5.89, p=0.015). The oxygenation index on day 3 was 312±45 mmHg in the study group versus 276±52 mmHg in the control group (p=0.002). Mortality was 3.8% (5/130) in the study group versus 5.8% (7/120) in the control group (p=0.48). Conclusions. The use of valve thoracostomy with an S-shaped drain significantly reduces the incidence of infectious complications and recurrent pneumothorax, shortens the length of hospital stay, and improves gas exchange parameters in patients with severe thoracic trauma. Keywords: thoracic injuries [D013898]; pneumothorax [D011030]; shock, hemorrhagic [D012771]; chest tubes [D015505]; thoracostomy [D013906]; rib fractures [D012253]; postoperative complications [D011183]; tomography, X-ray computed [D014057]; pulmonary gas exchange [D011659]; emergency medicine [D004635].> < 0.05.

Results. In the study group, the incidence of infectious complications was 8.5% (11/130) compared with 23.3% (28/120) in the control group (χ²=11.24, p=0.001; OR=0.31, 95% CI 0.15– 0.64). The median length of hospital stay for isolated severe thoracic trauma was 6 days [IQR 5–8] in the study group versus 13 days [IQR 10–16] in the control group (U=2847, p < 0.001). Recurrent pneumothorax developed in 1.5% (2/130) of patients in the study group versus 7.5% (9/120) in the control group (χ²=5.89, p=0.015). The oxygenation index on day 3 was 312±45 mmHg in the study group versus 276±52 mmHg in the control group (p=0.002). Mortality was 3.8% (5/130) in the study group versus 5.8% (7/120) in the control group (p=0.48).

Conclusions. The use of valve thoracostomy with an S-shaped drain significantly reduces the incidence of infectious complications and recurrent pneumothorax, shortens the length of hospital stay, and improves gas exchange parameters in patients with severe thoracic trauma.

Relevance. Joint arthroplasty is a surgical method for treating deforming osteoarthritis, the use of which is increasing annually. With improved access to replacement therapy for patients with hemophilia, arthroplasty has become an effective treatment for hemophilic arthropathy. As the number of surgeries grows, the number of complications inevitably rises, one of which is periprosthetic joint infection. A significant problem is infection recurrence, which according to international data can reach 23.1%. In the case of hemophilia patients, the proportion of recurrent infections is 50%. Risk factors for recurrence of periprosthetic joint infection in patients with hemophilia require further study, which will enable the prevention of infectious complications following joint arthroplasty.

Objective. To analyze periprosthetic joint infections in patients with hemophilia and recurrences of this complication, as well as to assess the impact of various risk factors on the probability of recurrence.

Materials and Methods. A retrospective study analyzed cases of periprosthetic joint infection in patients with hemophilia who underwent surgical treatment between 2015 and 2024. Risk factors present at disease onset were identified and their influence on the likelihood of infection recurrence was evaluated.

Results. 102 surgical interventions in 47 patients were analyzed. Recurrences of periprosthetic joint infection occurred in 56.9% of cases. The overall probability of recurrence increases by the 40th month post-intervention to 64%. In hemophilia B, the probability of recurrence reaches 71% by 12 months. The age group most at risk is patients with onset at 60 years of age and older. A single-stage treatment protocol carries the highest chance of recurrence. The affected joint, antibiotic resistance of the pathogen, and markers of viral hepatitis did not have a significant influence. Intraoperative blood loss of less than 400 ml increases the risk of infection recurrence. Revision status of the prosthesis increases the probability of recurrence by 2.86 times. Polymicrobial infection has higher chances of recurrence.

Conclusions. Significant correlations were found between certain risk factors: specifically, hemophilia B and a single-stage treatment protocol with prosthesis retention increase the risk of recurrence. Prosthesis status, the number of pathogens, and patient age increase the likelihood of recurrence, which aligns with global literature data. Intraoperative blood loss is likely a non-relevant factor, as it does not account for total blood loss.

Background. The problem of closing extensive wound defects remains a challenging task in modern surgery. The increasing number of technogenic disasters, road traffic accidents, military operations, and terrorist attacks leads to a rise in patients with extensive soft tissue defects that cannot be managed using conventional suturing techniques.

Objective. To analyze the current state of the problem of wound defect closure using acute and gradual tissue stretching methods based on domestic and international literature data.

Materials and methods. An analysis of scientific publications on tissue distraction methods from PubMed, eLibrary, and CyberLeninka databases was conducted. The design features and clinical effectiveness of modern devices for exogenous tissue stretching were reviewed.

Results. A classification of wound adaptation-repositioning devices (WARD) is presented, divided into five subgroups: needle-type, suture-type, wire-type, rod-type, and adhesive-type. The principles of operation of intratissue devices (expanders) and extratissue devices are described. The advantages and limitations of each method, as well as indications and contraindications for their use, are analyzed. Current trends in device improvement, including automated tension control and mathematical justification of distraction parameters, are highlighted.

Conclusion. The method of gradual tissue distraction is a promising approach for treating patients with extensive wound defects, contributing to reduced hospitalization duration and treatment costs. Further development of new devices and algorithms adapted to individual wound defect characteristics is required.

Relevance. Inguinal hernia ranks first in the overall structure of pathology. The technique of surgical treatment of inguinal hernia by anterior and posterior approaches has been developed in detail. However, complications are possible with all surgical methods. Ultrasound allows us to determine the features of the anatomical structure of the inguinal region and identify complications after surgery when they develop, but the results of such studies are not yet sufficiently presented in the literature.

Objective: to evaluate the role of ultrasound for diagnosing inguinal hernia in men and women, assessing the condition of tissues in the inguinal regions and detecting complications after various surgical methods.

Object and methods. The analysis of treatment of 242 patients with inguinal hernia aged from 21 to 92 years was conducted. There were 217 men (89.7%), 25 women (10.3%). In addition to collecting clinical data, all patients underwent ultrasound of the inguinal regions before and after surgery. Additionally, using ultrasound, age-related changes in the tissues of the inguinal regions were studied in 50 patients aged 60-70 years without hernias. There were 43 men (86%), 17 women (14%). All operations were performed by the anterior combined method using mesh implants. Patients were divided into 2 groups. In group 1 (main), the operation was completed with wound drainage, in group 2 (comparison), wound drainage was not performed. Interventions were assessed by the nature and number of complications.

Results. It was found that according to ultrasound data in patients with and without hernias, the thickness of the subcutaneous tissue, the total thickness of the muscles and aponeurosis did not differ. The frequency of complications was affected by wound drainage at the final stage of the intervention. This made it possible to reduce the frequency of seromas by 3.9 times, hematomas - by 4.3 times, suppurations - by 4.3 times in group 1 compared to group 2 (p < 0.001).

Conclusions. In patients with inguinal hernia, ultrasound allows confirming the diagnosis, assessing the condition of tissues in the groin area, identifying wound complications and eliminating them at an early stage. In patients with inguinal hernia, when performing anterior prosthetic methods of plastic surgery, it is necessary to complete the operation with wound drainage, which improves immediate and remote treatment results. Logistic regression of complication predictors showed that the frequency of complications was statistically significantly higher in patients with unilateral right-sided hernias compared to left-sided inguinal hernias.

Background. Congenital clubfoot is one of the most common musculoskeletal deformities in children, occurring with a frequency of 0.6–1.5 cases per 1000 live births. Despite the high effectiveness of the Ponseti method, the recurrence rate reaches 40%, which represents a serious problem in pediatric orthopedics.

Objective — to summarize and systematize current data on the epidemiology, risk factors for the development of congenital clubfoot and methods of correcting its recurrence.

Materials and methods. A search and analysis of publications was conducted in the E-library and PubMed databases using the keywords "clubfoot recurrence", "clubfoot relapse" for the period 1964–2025. The descriptive review included 83 relevant clinical studies, reports and systematic reviews.

Results. It was found that the prevalence of clubfoot varies depending on geographic region (from 0.51 to 2.03 per 1000 live births) and ethnicity. The recurrence rate after Ponseti method treatment is 10–30%, after surgical treatment — 20–50%. The leading risk factors for recurrence are: non-compliance with brace wearing protocol (increases risk by 5.4 times), high initial Pirani score, age at treatment initiation over 3 months, bilateral clubfoot. An algorithm for selecting the recurrence correction method is presented depending on the patient's age and nature of deformity: from repeated Ponseti casting to complex reconstructive interventions (tendon transpositions, osteotomies, arthrodeses).

Conclusion. Clubfoot recurrences remain a relevant problem requiring a multidisciplinary approach. Key prevention factors are strict adherence to orthosis wearing protocol and regular follow-up. When recurrence develops, the choice of treatment method should be individualized considering the patient's age, severity of deformity and previous treatment. Further research is needed to standardize recurrence diagnostic criteria and develop innovative treatment methods.

Background. Polyneuropathy is one of the complications of critical limb ischemia. In 30% of patients with critical limb ischemia, polyneuropathy occurs solely as a result of chronic tissue ischemia and is termed "ischemic polyneuropathy." In the diagnosis of ischemic polyneuropathy, clinical assessment is paramount due to the limited information yield of electrophysiological examination methods. This necessitates the study of diagnostic features characterizing ischemic polyneuropathy.

Objective. To determine the clinical and instrumental characteristics of ischemic polyneuropathy in patients with critical limb ischemia.

Patients and methods. From October 2, 2023, to March 31, 2025, patients with critical limb ischemia hospitalized in the Emergency Vascular Surgery Department of the N.V. Sklifosovsky Research Institute for Emergency Medicine. Patients underwent neurological assessment, sural nerve stimulation electroneuromyography, and assessment using the Neuropathy Disability Score (modified), the Neuropathy Symptom Score, and the Douleur Neuropathique 4 to determine the type of pain.

Results. Ischemic polyneuropathy was detected in 69% (n=45/65) of patients with critical limb ischemia. In 71% (n=32/45), ischemic polyneuropathy was accompanied by neuropathic pain. The most common symptoms of ischemic polyneuropathy were decreased vibration sensitivity (82-89%) and absent Achilles reflex (82%). A comparative analysis of clinical and laboratory data revealed that patients with ischemic polyneuropathy were less likely to have undergone coronary artery bypass grafting in the past, and the proportion of those taking atorvastatin and an antiplatelet agent in patients with ischemic polyneuropathy was lower (0/45 vs. 10 (2/20) (p=0.031); 13 (6/45) vs. 35 (7/20) (p=0.044); 13 (6/45) vs. 35 (7/20) (p=0.044), respectively).

Conclusions. Pain associated with critical limb ischemia may be caused by ischemic polyneuropathy. The most common symptoms of ischemic polyneuropathy are neuropathic pain, impaired vibration sensation, and absent Achilles reflex. The absence of HMG-CoA reductase inhibitors, antiplatelet therapy, and the absence of a history of coronary artery bypass grafting are associated with ischemic polyneuropathy in patients with critical lower limb ischemia.

The relevance of the study lies in the fact that acral skin melanoma is a subgroup of skin melanoma diseases characterized by a more malignant course.

The aim of the study was to investigate certain medico-social features of a group of patients with acral skin melanoma.

The materials and methods included data from the population cancer registry, outpatient cards, and medical histories of the entire general population of patients with skin melanoma, acral melanoma, and various benign skin neoplasms who received treatment at the State Budgetary Healthcare Institution Samara Regional Clinical Oncology Dispensary (GBUZ SOKOD) from 2000 to 2022. Two groups were formed: 233 patients with verified acral melanoma (66 men, 167 women) and 415 patients with benign skin neoplasms. Analysis was conducted on anatomical localization, internal environment factors (comorbid autoimmune diseases, phenotypic traits, presence of other malignant neoplasms and melanoma in history), and external social factors (education, patient awareness of disease signs, initiator of medical consultation).

Results: Acral melanoma predominantly affects the lower extremities (71.67%), especially the nail phalanx of the first toe (47.9%); among patients with acral melanoma, higher education prevails (42.29%) and awareness of melanoma signs is 45.06%; consultation initiation is mostly self-initiated (80.63%); autoimmune diseases and family history of melanoma are rare (<3%); light phenotype dominates (blondes — 88.3%). Conclusions: Acral skin melanoma is characterized by specific localization and low hereditary predisposition; social factors (education, awareness) contribute to early diagnosis, emphasizing the need for enhanced health education to reduce mortality. Keywords: melanoma [D008545]; melanoma [D008545]; skin neoplasms [D012878]; epidemiology [D004813]; risk factors [D012307]; early diagnosis [D055088]; health education [D006266]; autoimmune diseases [D001327]; family history [D005192]; phenotype [D010641]>< 3%); light phenotype dominates (blondes — 88.3%).

Conclusions: Acral skin melanoma is characterized by specific localization and low hereditary predisposition; social factors (education, awareness) contribute to early diagnosis, emphasizing the need for enhanced health education to reduce mortality.

Background. Trophic disorders of the lower extremities in diabetes mellitus and chronic obliterating diseases of the arteries of the lower extremities pose a complex therapeutic problem due to the high risk of amputations (5–24% within 6–18 months) and frequent relapses (40% within a year). The pathogenesis is caused by tissue ischemia due to macro- and microangiopathy, atherosclerotic arterial occlusion and microcirculation disorders. The low effectiveness of standard therapy and the lack of individual approaches to predicting the duration of remission determine the need to develop personalized treatment methods.

Objective. A method has been developed to determine the duration of the clinical effect after treatment with an oxygen-helium mixture in patients based on quantitative data characterizing the state of the pathological process before the start of therapy using multidimensional linear regression analysis.

Materials and methods. A multidimensional linear regression analysis of a number of parameters characterizing the clinical condition of the patient's body in the treatment of patients with diabetes mellitus, chronic obliterating diseases of the arteries of the lower extremities, and trophic ulcers was performed. The study was conducted using clinical data from 50 patients.

Results. A reliable range of indicators was obtained (diastolic blood pressure, LDL (mmol/L), duration of the disease (year), intermittent claudication (m), body temperature in degrees Celsius, UO (ml), height (cm), HDL (mmol/l), cholesterol (mmol/l), affecting the results ongoing therapy. A method for calculating the duration of remission in a particular patient has been developed. The results obtained will improve the quality of care and the correctness of prescribing combination therapy, which in turn will reduce the frequency of surgical procedures.

Conclusion. A methodology has been developed for determining the timing of repeated oxygen-helium therapy courses.

Background. Hidradenitis suppurativa (HS) is a severe chronic inflammatory disease affecting apocrine gland-bearing skin, characterized by a persistent relapsing course with abscess formation, sinus tracts, and scarring. The disease significantly impairs patients' quality of life and leads to substantial social disability. The lack of standardized treatment approaches necessitates the systematization of surgical experience.

Objective. To evaluate the effectiveness of radical surgical treatment for extensive chronic hidradenitis suppurativa.

Materials and methods. The study included 15 patients (14 males, 1 female) aged 20 to 60 years with a prolonged disease history and multiple previous surgical interventions. Disease severity was assessed using the H.J. Hurley classification (1989). All patients were diagnosed with Hurley stage II or III disease. The condition was predominantly multilocal: 47 affected sites were identified in 15 patients. Surgical treatment consisted of radical excision of pathologically altered tissues followed by wound irrigation and primary closure. When primary closure was not feasible, split-thickness skin grafting was performed. No more than two anatomical regions were operated on during a single hospitalization.

Results. In stage II disease, primary wound healing was achieved in 100% of cases. In stage III, primary wound closure was possible in 50% of cases; the remaining cases required skin grafting. At long-term follow-up (12 months postoperatively), no disease recurrence was observed in any patient.

Conclusion. Radical surgical excision of affected tissues is an effective treatment method for Hurley stage II–III hidradenitis suppurativa, ensuring no recurrence within one year of follow-up. In stage III disease, primary skin grafting is advisable for closure of extensive postoperative defects. Keywords:

Background. Pulmonary hemorrhage (PH) presents a complex challenge in various lung diseases. Given the high mortality rate (70%) prior to the introduction of embolization, PH requires rapid assessment and stabilization, airway protection, and identification of the bleeding source for definitive intervention.

Objective: To identify the causes of pulmonary hemorrhage, determine the bleeding source, and evaluate treatment methods.

Materials and Methods. The study included 132 patients admitted and 17 patients transferred to the institute with pulmonary hemorrhage of various etiologies, hospitalized in the intensive care unit (11 patients) and thoracic surgery department (138 patients), requiring diagnosis and various emergency interventions (angiography, embolization, fiberoptic bronchoscopy, bronchial occlusion, bronchial stenting).

Results. Manifestations of PH in various pathologies were demonstrated, and diagnosis and treatment were performed. The Grigoryev E.G. classification (1A, 1B, 1C, 2A, 2B, 3A, 3B) was used to determine PH severity. The primary diagnostic methods for PH were computed tomography with intravenous bolus contrast enhancement, fiberoptic bronchoscopy, and esophagoscopy, based on which, along with clinical presentation data, treatment strategy was determined. Emergency care was based on examination results, including angiography, and utilized endoscopic and minimally invasive treatment methods (angiography, embolization of bronchial and other arteries, aortic stenting) as well as conservative management. The indication for angiography and endovascular embolization in patients with mild or moderate hemoptysis was bleeding unresponsive to conservative management. The prognosis of PH depends on several factors, including the speed of diagnosis and bronchial artery embolization (BAE), the need for bronchial occlusion, considering the patient's general condition and presence of comorbidities. When BAE is ineffective, angiographic investigation is necessary to identify additional sources, specifically non-bronchial arteries.

Conclusions. In mild to moderate PH, treatment is based on comprehensive diagnosis and early detection of PH through angiography and BAE. In cases of massive PH, bronchial occlusion should be performed as part of comprehensive management, and when BAE is ineffective, angiographic investigation is necessary to identify additional bleeding sources: non-bronchial arteries. Temporary hemostasis is advisable to avoid emergency surgery. The high recurrence rate of PH (50%) and PH recurrence (10%) after emergency embolization and previous embolization necessitate performing BAE in all cases, additional angiographic investigation, and subsequent treatment of the underlying pathological process.

Relevance. Listeriosis is an urgent public health problem, as it can affect the central nervous system with listeriosis meningitis and meningoencephalitis development. The disease is characterized by high mortality, which is especially dangerous for immunocompromised populations. It spreads mainly through food products, which causes serious risks to public health, and considering the food industry globalization, the listeriosis spread problem is becoming international.

The aim of the study: is to determine the listeriosis meningoencephalitis clinic, diagnostics and treatment features at the present stage.

Material and methods. The work was carried out on the basis of the clinic and the department of infectious diseases with epidemiology of the Samara State Medical University. From June 2023 to March 2025, 137 patients with meningitis diagnosis were treated. Clinical, laboratory, epidemiological, and statistical analysis were conducted.

Results. Of the 137 patients diagnosed with meningitis, 90 had serous meningitis and 47 had purulent meningitis. In a third of the cases, the diagnosis was not etiologically confirmed. In seven cases, listeriosis meningitis was identified, and the diagnosis was confirmed by the Listeria monocytogenes detection in the cultures. The clinical manifestations, changes in peripheral blood and cerebrospinal fluid features, etiotropic treatment choice have been determined.

Conclusion. The neurolisteriosis proportion among other etiologies meningitis remains high and tends to increase in immunocompromised patients. The neurolisteriosis clinical picture is not specific. In patients with neurolisteriosis, the cerebrospinal fluid general and biochemical parameters do not correspond to each other: 2-3-digit pleocytosis was detected in combination with elevated protein and lactate levels, accompanied by a pronounced decrease in cerebrospinal fluid glucose. Gram-positive rods detection by cerebrospinal fluid microscopy, taking into account the cerebrospinal fluid examination results, makes it possible to suspect neurolisteriosis and timely prescribe appropriate antibacterial therapy. It is advisable to perform cerebrospinal fluid PCR for DNA Listeria monocytogenes in immunosuppressed patients during the meningitis diagnosis and differential diagnosis. In the neurolisteriosis case, an effective treatment regimen includes the carbapenems and aminoglycosides use. Alternative treatment regimens include penicillins, co-trimoxazole, linezolid and levofloxacin.

Ингибиторы тирозинкиназы благоприятно влияют на прогноз и продолжительность жизни пациентов с хроническим миелолейкозом. В то же время, описано негативное влияние некоторых из них на сердечно-сосудистую систему. Исследование сократительной функции левого желудочка на основе продольной деформации является на сегодняшний день наиболее информативным методом отображения миокардиальной работы.

Цель: проанализировать показатели, влияющие на развитие кардиотоксичности у пациентов с хроническим миелолейкозом, находящихся в процессе терапии бозутинибом в суточной дозировке 500мг.

Материалы и методы. В исследование включено 47 человек (мужчин 30 (63,8%)/ женщин 17 (36,2%), медиана возраста 49,0 (46,5;53,0) лет с диагнозом хронический миелолейкоз перед началом терапии бозутинибом. Всем пациентам было проведено исследование стандартных клинических, лабораторных и инструментальных показателей, а также трансторакальная эхокардиография с определением глобальной продольной деформации левого желудочка.

Результаты. Зафиксирована прогрессия артериальной гипертензии до 2 степени к 12 месяцу у 6 (12,8%) и формирование у 2 (4,25%) пациентов (р=0,112) стабильной стенокардии I ФК и ХСН I ФК (NYHA). Уровень общего холестерина увеличился (4,9 (4,36;5,31) ммоль/л до терапии против 4,91 (4,2;5,46) ммоль/л, < 0,001) к 12 месяцу терапии и ХС ЛПН (2,31 (1,76;3,04) ммоль/л до терапии против 2,3 (1,72;2,58) ммоль/л, p=0,009) к 6 месяцу. У всех пациентов к 12 месяцу выявлялось увеличение размеров (КДР 50,0 (46,0;51,0) мм и КСР 31,5 (30,0;34,0) мм до терапии против 53,0 (49,0;54,0) мм и 33,5 (32,0;36,0) мм, p < 0,001) и объема левого желудочка (КДО 111,0 (97,0;127,75) мл и КСО 57,0 (51,0;59,0) мл до терапии против 116,5 (98,75;130,0) мл и 58,0 (53,0;61,75) мл, p < 0,001). Снижение фракции выброса левого желудочка к 12 месяцу (60,0 (59,0;62,0) % до терапии против 59,0 (57,25;60,0) %, p < 0,001) расценивалось как нарушение систолической функции. К 12 месяцу у 5/47 (10,64%) было отмечено снижение глобальной продольной деформации 21,5(18,6;21,6) до терапии против 14,5(14,2;14,7), p < 0,001).

Выводы. Проведенный анализ совокупности показателей, позволяет говорить о развитии кардиотоксичности у части пациентов 5/47 (10,64%) с хроническим миелолейкозом, находящихся на терапии бозутинибом, что подтверждается выявленным снижением глобальной продольной деформации левого желудочка. Полученные данные следует интерпретировать как необходимые для дальнейшего наблюдения и проведения своевременной коррекции.

Plasmablastic lymphoma (PBL) is a rare and aggressive B-cell lymphoma associated with immunodeficiency states, primarily with HIV infection, and Epstein–Barr virus (EBV). The coexistence of PBL and pregnancy represents an exceptional rarity. This article presents a clinical case of a 31-year-old patient with stage IV HIV infection (WHO clinical stage) without antiretroviral therapy (ART). At 25–26 weeks of gestation, the patient was diagnosed with generalized PBL involving the skin, lymph nodes, mammary glands, lungs, liver, and brain. The disease was complicated by disseminated pulmonary tuberculosis and cytomegalovirus infection, and ended with an unfavorable obstetric outcome – maternal death following cesarean section. This case illustrates the aggressiveness of PBL during pregnancy in the setting of profound immunodeficiency, emphasizing the importance of early HIV detection, initiation of ART in women of reproductive age, and a multidisciplinary approach to the management of such patients.

The maxillary artery demonstrates considerable anatomical variability, creating substantial challenges in preoperative planning for maxillofacial surgical interventions. Traditional preoperative imaging methods require significant time for data interpretation and depend heavily on specialist expertise. The accumulation of large DICOM medical image datasets creates prerequisites for applying machine learning methods and deep neural networks to automate vascular structure analysis. This work presents a conceptual rationale for applying artificial intelligence technologies to identify anatomical variations of the maxillary artery based on computed tomography and cone-beam computed tomography data analysis. We analyze the current state of deep learning algorithm applications in medical visualization of head and neck vascular structures, systematize known anatomical variations of the maxillary artery and their clinical significance, and formulate technical requirements for potential automated analysis system architecture. The proposed conceptual approach includes using convolutional neural networks for semantic segmentation of the vascular network, three-dimensional reconstruction algorithms for visualizing topographic relationships, and a classification system for identified structural variants by surgical risk degree. We substantiate the necessity of creating a specialized training dataset of annotated maxillary artery images to ensure high recognition accuracy. We discuss potential advantages of automated analysis, including standardization of diagnostic approaches, reduction of preoperative planning time, and minimization of intraoperative complications related to vascular injury. We acknowledge existing technical and organizational limitations of implementing such systems, including the need for validation on large clinical cohorts and integration into existing medical information systems.

Background. Despite being less invasive compared to axillary lymph node dissection, sentinel lymph node biopsy in breast cancer remains a procedure associated with the risk of developing lymphorrhea and lymphedema. One theoretically justified approach to preventing these complications is autologous fat tissue transplantation to fill the postoperative tissue defect; however, the evidence base for this method is absent, and the optimal transplant volume has not been determined.

Objective. To obtain preliminary anatomical data on the volume of tissue defect formed during sentinel lymph node biopsy, depending on anthropometric parameters, to justify the design of a prospective clinical study.

Materials and Methods. A pilot anatomical study was performed on 12 female cadaveric specimens aged 65.1±16.9 years with different body mass indices. Sentinel lymph node biopsy simulation included a standardized incision, removal of level I lymph node with surrounding fat tissue, and measurement of residual defect volume using the plaster solution filling method followed by volumetry. Correlation analysis of defect volume dependence on body mass index and age was performed.

Results. The mean tissue defect volume was 3.5±0.6 cm³. A positive correlation was found with body mass index (r=0.70; p=0.012) and age (r=0.61; p=0.035). The largest volume was recorded at body mass index over 25 kg/m² and in the age group 72-82 years; the smallest – at body mass index less than 18.5 kg/m² and in the group 48–59 years.

Conclusions. Preliminary anatomical data on the variability of tissue defect volume during sentinel lymph node biopsy simulation were obtained. The results justify the need for a prospective clinical study to validate the in vivo measurement method and assess the clinical significance of personalized autograft volume selection. Cadaveric material has critical limitations and does not allow extrapolation of data to clinical practice.

A rare clinical case of a long-term asymptomatic presence of a metallic foreign body (surgical clamp) left in the abdominal cavity after cholecystectomy is presented, demonstrating the diagnostic difficulties and potential complications, and emphasizing the importance of a thorough revision of the surgical field and alertness to foreign bodies in the anamnesis. Clinical case. Patient G, 68-years-old female, was hospitalized in the Scientific Research Institute – Ochapovsky Regional Clinical Hospital №1 with the diagnosis: Abscessed foreign body (surgical clamp) in the abdominal cavity. From the anamnesis: a foreign body in the abdominal cavity was incidentally discovered during an X-ray examination of the spine in 2019, performed for unrelated reasons. Not extracted due to the patient’s unwillingness. The patient underwent emergency surgery, with technical difficulties, after complications developed.

Pathological processes of the endometrium represent an extensive group of diseases that require special vigilance. In practice, unjustified invasive interventions are often observed in elderly patients, which leads to a search for an approach to routing and treating postmenopausal women undergoing intrauterine interventions.

The purpose of this article is to study the management tactics of postmenopausal patients with endometrial pathology.

Materials and methods. The analysis of data from domestic and foreign literature and guidelines, as well as the medical history of 1 patient, was carried out on the basis of the gynecological department of the CHUZ KB RZD-Medicine Samara.

Results. A patient with a comorbid background and a long postmenopausal period (>15 years) underwent hysteroscopy with suspected uterine polyp, which revealed intrauterine synechiae. After 3 days, according to transvaginal ultrasound, hematometer complications with a suspected fibrin clot were detected.

Conclusions. This clinical case highlights the limited possibilities of ultrasound diagnostics in detecting focal changes in conditions of atrophic endometrium. Management tactics for postmenopausal patients with endometrial pathology should be based on the clinical picture, individual risk, and expediency of intervention. In the absence of symptoms and the presence of small formations, it is possible to choose a wait-and-see approach with regular ultrasound and pipel biopsy, avoiding unnecessary invasive procedures.

This clinical protocol outlines the application of Hypothermic Oxygenated Perfusion (HOPE) and Controlled Oxygenated Revascularization (COR) to enhance the quality of donor liver and kidney grafts. The protocol is based on international and domestic studies demonstrating reduced biliary complications and early graft dysfunction rates with machine perfusion. HOPE is recommended for organs from donors after circulatory death (DCD) and extended criteria donors (ECD), while COR is used for assessing marginal organs. The protocol includes detailed descriptions of indications, contraindications, technical aspects of perfusion, monitoring, and viability assessment using biomarkers such as flavin mononucleotide, succinate, and markers of apoptosis, necroptosis, and ferroptosis. The authors present their own results, confirming the effectiveness of these methods in reducing complications and improving transplantation outcomes.

Liver transplantation is a radical treatment for end-stage liver disease. Improved transplantation outcomes have led to an increasing number of women of reproductive age with functioning grafts, making pregnancy after liver transplantation an important clinical issue. Pregnancy following liver transplantation is associated with increased risks for both mother and fetus, including complications related to immunosuppressive therapy, graft dysfunction, and comorbidities.

Objective. To analyze pregnancy cases in women after liver transplantation, evaluate current research and international guidelines for patients of reproductive age following liver transplantation, and identify risk factors affecting pregnancy outcomes and maternal-fetal health.

Materials and methods. A literature search was conducted in PubMed, Scopus, Web of Science, eLibrary.ru, and Google Scholar databases for the period 2014-2025 using keywords: liver transplantation, pregnancy, pregnancy outcome, immunosuppressive therapy, rejection, preeclampsia. Inclusion criteria were original studies, systematic reviews, meta-analyses, clinical cases, and professional society guidelines. Exclusion criteria included publications without full-text access and duplicate data. A total of 36 sources were analyzed.

Results and discussion. According to literature data, live birth rates after liver transplantation range from seventy to eighty percent, however rates of preterm delivery (thirty to forty percent), preeclampsia (twelve to fifteen percent), and cesarean section (forty to fifty percent) significantly exceed those in the general population. Risk of graft rejection during pregnancy is three to ten percent. Major maternal complications include gestational hypertension, preeclampsia, gestational diabetes, and infectious complications. Most common fetal complications are intrauterine growth restriction, prematurity, and low birth weight. International guidelines emphasize the need for pregnancy planning no earlier than one to two years post-transplantation with stable graft function and absence of rejection episodes, as well as adjustment of immunosuppressive therapy to pregnancy-safe medications. Primary drugs of choice are tacrolimus and cyclosporine, while mycophenolate mofetil should be replaced with azathioprine at least six weeks before planned conception. Pregnancy management requires careful multidisciplinary monitoring involving a transplant surgeon, high-risk obstetrician, and neonatologist.

Conclusion. Pregnancy after liver transplantation is a complex process requiring a multidisciplinary approach and careful monitoring. Despite improved prognosis, pregnancy in these cases carries increased risks. Further research is needed to optimize pregnancy management, develop strategies to reduce graft rejection risk, and minimize complications.

Background. Traditional dental prosthetic methods are characterized by marginal fit errors of 100–200 μm, fabrication times of 2–6 weeks, and postoperative complication rates of 15–40%. Digital technologies — CAD/CAM systems, intraoral scanning, and additive manufacturing — represent a paradigm shift in prosthetic dentistry; however, systematized data on their clinical effectiveness and economic feasibility remain fragmented.

Aim. To conduct a systematic analysis of the accuracy, clinical effectiveness, and economic indicators of digital technologies in prosthetic dentistry compared to traditional methods.

Materials and methods. A systematic review was performed according to the PRISMA protocol. Searches were conducted in PubMed, Scopus, Web of Science, and Cochrane Library (2013–2023). Forty-seven studies were included: 23 randomized controlled trials, 18 prospective cohort studies, and 6 systematic reviews with meta-analysis. Cumulative sample: 6,284 patients, 8,917 prostheses. Primary endpoints: marginal fit accuracy (μm), fabrication time (days), complication rate (%). Secondary endpoints: patient satisfaction (OHIP-14), prosthesis cost (euros), corrective visits. Study quality was assessed using Cochrane Risk of Bias Tool 2.0 and NewcastleOttawa scales. Statistical analysis: weighted mean differences with 95% confidence intervals, meta-regression (RevMan 5.4, Stata 17.0).

Results. Digital technologies reduced marginal fit errors from 127.5 μm to 34.2 μm (weighted mean difference –93.3 μm; 95% CI: –102.1 to –84.5; p<0.001), representing a 73.2% relative improvement. Best results were achieved with monolithic zirconia crowns fabricated by CAD/CAM milling: 23.1 μm versus 134.2 μm (p><0.001). Median fabrication time for fixed prostheses decreased from 14 to 2 days (p><0.001). Chairside CAD/CAM technology enabled single-visit completion in 78% of cases (mean time 87 ± 23 minutes). The incidence of inflammatory complications at 12 months decreased from 14.8% to 6.2% (relative risk 0.42; 95% CI: 0.31–0.57; p >< 0.001). Temporomandibular joint dysfunction frequency decreased from 8.9% to 3.4% (relative risk 0.38; p = 0.001). Secondary caries developed in 2.8% versus 9.4% with traditional prosthodontics (relative risk 0.30; p<0.001). Cumulative survival of fixed prostheses at 24 months was 96.8% for digital versus 92.3% for traditional constructions (p=0.002). Mean OHIP-14 score: 41.2±6.3 versus 35.7±8.1 points (difference 5.5; 95% CI: 4.2–6.8; p><0.001). Adaptation time to removable prostheses decreased from 16.8 to 4.2 days (p><0.001). Cost per single crown decreased from €280 to €195 (30.4% savings). Economic efficiency is achieved with monthly volumes ≥12 prostheses, reaching break-even at 18–24 months. Implementation barriers: equipment cost €109,500–128,400, learning curve with optimal accuracy achieved after >100 procedures, post-processing of 3D-printed constructions required in 11.3% of cases, scanning artifacts in subgingival preparations in 8.4% of cases. Meta-regression revealed accuracy improvement of 0.142 μm per additional procedure (p=0.003).

Conclusions. Digital technologies demonstrate statistically and clinically significant superiority over traditional methods in marginal fit accuracy (73.2% improvement), fabrication time (7-fold reduction), complication rates (58–70% decrease), patient quality of life, and under certain conditions — economic indicators. Optimal cost-effectiveness is achieved in clinics with volumes ≥12 prostheses/month. Structured educational programs to overcome the learning curve, protocol standardization, and ensuring equitable access to technologies are critically important.

Currently, there is an increase in research into the Arctic region, recognized as a strategic resource that determines the future of our country, including in the field of medicine and health care. The experience of previous years is important for modern studies of the Arctic, especially for health-saving technologies. In the second half of the 20th century, a well-known role in research in this area belonged to the Problem Laboratory for the Study of Human Acclimatization in the Far North, created 60 years ago on the basis of the Arkhangelsk State Medical Institute.

The purpose of this study was to highlight the work of the Problem Laboratory for the Study of Human Acclimatization in the Far North as a unique Soviet project and to summarize its activities in honor of the 100th anniversary of the birth of its first heads - professors N.P. Neverova and A.I. Koreshkin.

The materials for the study were a wide range of historical sources: materials from state and personal archives, scientific publications, memoirs of employees and veterans, photo and video documents, monographs. The Problem Laboratory has been operating for almost 25 years and its effectiveness is beyond doubt. During the laboratory's existence, its employees have conducted dozens of expeditions, written hundreds of scientific articles, delivered dozens of reports at All-Union scientific conferences and defended many candidate and doctoral dissertations.

Based on the results of the Problem Laboratory's work, significant seasonal fluctuations in virtually all functions of the human body were established, the role of cold, humidity and high air velocity in changes in functional disorders of the body was established on experimental animal models, a computer program was created for processing large volumes of statistical data, changes in the autonomic nervous system, digestive organs, and cardiovascular system were established in people staying in the Far North for a short time, psychological problems were noted, methodological manuals and recommendations for favorable acclimatization to the conditions of the Far North were written, a medical weather forecasting system was developed in the European North of the country to minimize the risk of cardiovascular disasters and much more.

The existence of the Problem Laboratory left a significant mark on the history of medicine and science, and fully realized the potential that was originally embedded in it.

Background. Preserving the life and health of military personnel, including when performing the tasks of a special military operation, requires efforts not only from the medical services of the Ministry of Defense of the Russian Federation, but also from the scientific community, which should summarize the experience and knowledge gained so far, with a scientific rethink of surgical and therapeutic approaches to the treatment of the wounded and the development of new organizational technologies. providing medical care on the battlefield and during evacuation. Publication activity in military medical journals is a reflection of the results of research activities in the field of military medicine and is measured by the number of scientific articles published in them.

Objective. Evaluation of the publication activity of the results of scientific research of military medical orientation in specialized peer-reviewed scientific journals.

Research materials: Рublications presented in three main scientific journals on military medicine reviewed by the Higher Attestation Commission for the period 2021–2025 (1,468 publications). Methods: overview of the subject field.

Results. 51.8% of the publications dealt with military topics, of which 21.1% were on the organization of military healthcare, 29.6% on military surgery, therapy and rehabilitation. During the period 2021-2025, the share of publications related to military education in the structure of military publications increased from 2% to 34%. The share of military-related publications increased from 51.3% in 2021 to 61% in 2025.

Conclusion. The review of publications testifies to continuous scientific work in the field of "military healthcare", military surgery, therapy and rehabilitation, as well as to summarize the experience of military medicine during its period.

Relevance. Injuries sustained during combat operations in modern conditions are characterized by a significant degree of tissue destruction and contamination, and have nothing to do with what is observed in peacetime injuries. This is convincingly confirmed by statistical data on the conduct of a special military operation (SVO), published in the medical literature. The use of radiation research methods in explosive lesions with limb damage is the basis for determining the degree of damage, establishing a correct diagnosis and evaluating the use of osteosynthesis.

Purpose. To determine the importance of classical digital radiography in the diagnosis of limb injuries in explosive injuries at the stage of specialized medical care, both during the initial examination of the wounded and during sequential osteosynthesis.

Materials and methods. The medical histories and 854 X-ray examinations of 110 victims with explosive limb injuries were retrospectively analyzed. Radiographs were evaluated before and after osteosynthesis, when changing the type of osteosynthesis, during dynamic monitoring and the occurrence of complications. All the wounded were men, with an average age of 34.8±7.7 years.

Results. When analyzing the data, it was revealed that lower extremities are more often damaged by modern weapons – 61.21%, namely fractures of the shin bones – 29.09%. Radiographs revealed the following complications: gunshot osteomyelitis, false joint – in 14.5% of cases. The occurrence of a relatively small number of complications is associated with a large number of wounded (31.48%) who were admitted to the hospital from 2 to 7 days after receiving wounds. 2.7% had osteomyelitis and the formation of a false joint. Delayed consolidation during fixation by various types of metallosynthesis was observed in 86.36% of the injured. Osteomyelitis was suspected by X–ray in 7.27% of the injured, confirmed by computed tomography (CT) (62.5%), confirmed by fistulography (50%). In 10% of the victims, a false joint was detected on X-rays, and the presence of a false joint was confirmed by CT in 54.54% of the victims.

Conclusion. Classical digital radiography is a basic study and cannot be replaced with intraoperative radiotherapy to perform osteosynthesis, as well as to assess the dynamics of the wound process of bone structures of the limb under conditions of fixation by various types of osteosynthesis. However, there are limitations of the method, and CT is additionally used to reliably assess the condition of bone and soft tissue structures.

Relevance. Hypertensive disorders complicate up to 10% of pregnancies, making a significant contribution to the statistics of maternal and perinatal morbidity and mortality. Placental dysfunction is a key factor in the pathogenesis of these complications. Ultrasound examination (US) with Dopplerometry, although it is considered the standard for assessing blood flow in the mother-placenta-fetus system, is limited in its ability to visualize structural changes in the placenta. Magnetic resonance imaging (MRI), due to its high tissue contrast and spatial resolution, is considered as a promising non-invasive method that can complement existing approaches to assessing the placental condition in hypertensive disorders.

Objective. To describe placental structural changes in pregnancies complicated by hypertensive disorders based on MRI data and to compare the results with those of ultrasound and histopathological examination.

Materials and methods. A prospective case-control pilot study was conducted involving 13 pregnant women with hypertensive disorders in the second and third trimesters. Each placenta was studied using 3T MRI (standard sequences), ultrasound with Dopplerometry, and subsequent histopathological examination after delivery.

Results. In 13 patients (mean age 33.7±6.1 years), MRI revealed characteristic structural changes: diffuse areas of reduced MR signal on T2-weighted images (in 100% of cases), high lobularity (54%) and granularity (54%), as well as circulatory disorders: infarcts (69%) and hematomas (38%). Histopathological changes were detected in 85% of cases. In 38% of cases, MRI detected alterations when the Dopplerometry results were within normal ranges. The severity of the changes correlated with the severity of hypertensive disorder and adverse pregnancy outcomes.

Conclusion. MRI enables the detection of characteristic structural changes in the placenta in hypertensive disorders, which directly reflect vascular, immune-inflammatory, and other microscopic lesions. These changes can be pronounced even with normal Doppler measurements and are associated with adverse pregnancy outcomes. MRI provides additional information about the condition of the placenta in hypertensive disorders, opening up prospects for improving the management of such pregnancies.

Introduction. Musculoskeletal diseases and injuries are a pressing problem for millions of people. Damage to the hyaline cartilage leads to further degradation of the articular surface. Conservative treatment methods are ineffective, and at the final stage, a highly traumatic, costly procedure of joint arthroplasty is required. After it, in 3% of cases, complications occur in the form of periprosthetic infection, the treatment of which requires significant additional economic costs, reducing the quality of life and increasing the risk of disability of patients. Of particular interest is the prediction of recurrence of periprosthetic infection associated with the chronicity of the process and a significant increase in the duration of treatment and its costs.

The aim of the study. Creation of a structured database for subsequent analysis of factors influencing the risk of recurrence of periprosthetic infection of the hip joint using the Python programming language based on archival data of patients with hip joint arthroplasty.

Materials and methods. The work was carried out using information about patients with periprosthetic infection of the hip joint, who were treated at the Center in the period from 2010 to 2022. Discussion. The obtained data allow predicting the risk of recurrent PJI, as well as analyzing the causes leading to it, which will allow adjusting the further treatment regimen for such patients in order to avoid or minimize the development of recurrent periprosthetic infection.

Results. A structured database of cleaned and prepared data for further analysis was obtained with 1611 unique patients, each of whom was described by 101 unique attributes. The possibility of predicting the risk of developing periprosthetic infection based on the information obtained using an automatic algorithm was shown.

Conclusion: further analysis of the data bank will allow us to deepen our understanding of the causes of recurrent periprosthetic infection and consolidate the experience of traumatologists and orthopedists regarding the management of this cohort of patients.